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Cosmetic Peat Association
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Fulvic Acids

Chemical Compounds
Also: FA, fulvic acid, fulvate, oxifulvic acid
Molecular weight: 1,000–10,000 Da
Solubility: Soluble at all pH values
Concentration in peat: 5–20% of dry mass, higher ratio in sphagnum peat

Fulvic acids are the low-molecular-weight fraction of humic substances in peat. Unlike humic acids, fulvic acids are soluble at all pH values, giving them higher bioavailability and skin penetration potential. They are yellow to light brown in color and represent a larger proportion of the humic fraction in sphagnum-derived peat compared to lowland peat.

Structure

Smaller and more oxygenated than humic acids, with a higher density of carboxyl (–COOH) and hydroxyl (–OH) functional groups per unit mass. This gives fulvic acids greater reactivity, chelation capacity, and water solubility despite their smaller size.

Bioavailability Advantage

The key distinction from humic acids is bioavailability. Fulvic acids can penetrate skin more readily due to their lower molecular weight. This makes them potentially more effective per unit mass in topical applications, though they are present in lower absolute quantities in most peat types.

Cosmetic Relevance

Increasingly of interest in cosmetic formulations as a mineral delivery vehicle and antioxidant. The ability to chelate minerals and transport them across biological membranes makes fulvic acids relevant for both transdermal mineral delivery in balneotherapy and active ingredient enhancement in topical products.

Evidence & Claims

exhibits anti-inflammatory (strong)

Inhibits CCL17/CCL22 via p38 MAPK/JNK pathways; suppresses NF-κB activation; reduces TNF, IL-6 while preserving IL-10

van-rensburg-2015 — Section on fulvic acid biological activities
wu-2023 — FA inhibits CCL17/CCL22 in keratinocytes via p38 MAPK and JNK deactivation; dose-dependent in DNCB-induced AD mice
szwed-georgiou-2026 — FA suppresses NF-κB via LPS neutralization and receptor-level inhibition; reduces TNF and IL-6 without impairing IL-10
benderskiy-2022 — Review confirms FA anti-inflammatory properties; promotes IL-10 overexpression
exhibits antioxidant (strong)

Potent free radical scavenger, chelates pro-oxidant metal ions

winkler-2018 — Antioxidant capacity of fulvic acids from peat extracts
exhibits mineral-delivery (strong)

Acts as natural chelator enhancing bioavailability of trace minerals through skin — proven to permeate human skin in vitro

pant-2014 — Fulvic acid as mineral transporter in biological systems
beer-2003b — Fulvic acid fractions 7–11 and 14 demonstrated to permeate excised human skin
exhibits antimicrobial (preliminary)

Some antiviral and antibacterial activity reported, less studied than humic acids

van-rensburg-2015 — Brief coverage of fulvic acid antimicrobial properties
gvozdeva-2025 — Review confirms FA antimicrobial and antiviral properties including viral fusion inhibition
exhibits wound-healing (moderate)

Promotes fibroblast proliferation (3× control), angiogenesis, and wound closure; reduces inflammatory cell infiltration in wound bed

samiee-rad-2022 — 0.5% FA poultice: fibroblasts 45 vs 14.87 (week 1), angiogenesis 25 vs 7.12 (week 1), all p<0.05 in rat model
szwed-georgiou-2026 — MLG-A50 FA showed pro-regenerative effect in wound healing scratch assay — increased wound closure rate in LoVo cells
benderskiy-2022 — Review: carbohydrate-derived FA promotes wound healing via Nrf2 pathway and IL-10 overexpression
exhibits anti-pruritic (moderate)

Inhibits β-hexosaminidase and histamine release from mast cells, decreases intracellular Ca²⁺ — antiallergic mechanism relevant to itch and allergic skin reactions

yamada-2007 — CP-FA inhibits β-hexosaminidase release at antigen-antibody and antibody-receptor binding stages (p<0.05); inhibits histamine release from KU812 human basophilic cells; decreases intracellular [Ca²⁺]i
ubner-2013 — Review confirms FA antiallergic effect — inhibits β-hexosaminidase and histamine release, decreases intracellular calcium
exhibits chelation (strong)

High chelation capacity per unit mass due to abundant carboxyl groups; acts as transport agent for trace metals in peat

stevenson-1994 — Chapter 9 — fulvic acid metal binding constants
orru-2011 — FA correlates with Cd (r=0.91), Th (r=0.86), Zn (r=0.76) in Estonian peatlands — FA acts as metal transport/storage agent