Evaluation of Healing Effects of Poultice Containing 0.5% Fulvic Acid on Male White-Male Rats with Skin Ulcer
Key Findings
- 0.5% FA poultice significantly increased fibroblast proliferation vs control: week 1 (45 vs 14.87), week 2 (75 vs 28.75), week 3 (114.75 vs 75.12), all p<0.05
- FA poultice significantly enhanced angiogenesis: week 1 (25 vs 7.12), week 2 (45 vs 14), week 3 (17.62 vs 5), all p<0.05
- Inflammatory cell infiltration (neutrophils, eosinophils, mast cells) significantly decreased in FA treatment group
- FA acts as anti-inflammatory by decreasing proinflammatory mediator release
- FA modulates redox state and immunomodulatory function promoting tissue repair
In vivo rat study evaluating 0.5% fulvic acid poultice on full-thickness skin ulcers. 24 male Sprague Dawley rats divided into control, sham, and FA treatment groups. FA poultice significantly accelerated wound healing through three mechanisms: enhanced fibroblast proliferation (3× control by week 1), increased angiogenesis (3.5× control by week 1), and reduced inflammatory cell infiltration. The anti-inflammatory effect was attributed to decreased proinflammatory mediator release, while the pro-regenerative effect was linked to FA’s immunomodulatory and redox-modulating properties.
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0.5% FA poultice: fibroblasts 3× control, angiogenesis 3.5× control in rat wound model
FA poultice: significantly increased fibroblasts, angiogenesis, reduced inflammatory cells
0.5% FA poultice: fibroblasts 3× control, angiogenesis 3.5× control in rat wound model
FA poultice: significantly increased fibroblasts, angiogenesis, reduced inflammatory cells
0.5% FA poultice: fibroblasts 45 vs 14.87 (week 1), angiogenesis 25 vs 7.12 (week 1), all p<0.05 in rat model
0.5% FA poultice in rats: fibroblasts 3× control at week 1, angiogenesis 3.5× control, reduced inflammatory cells — all p<0.05