Fulvic Acid Attenuates Atopic Dermatitis by Downregulating CCL17/22
Key Findings
- FA reduces CCL17 (TARC) and CCL22 (MDC) expression in TNF-α/IFN-γ-stimulated HaCaT keratinocytes
- FA inhibits CCL17 and CCL22 production by deactivating p38 MAPK and JNK signaling pathways
- Dose-dependent inhibition: 200 and 500 μg/mL FA reduced mRNA of TNF-α, IL-6, CCL2, CCL17, CCL22
- DNCB-induced AD mouse model: topical FA reduced ear thickness, erythema, edema, and desquamation
- FA dose-dependently reduced serum CCL17 and CCL22 levels in AD mice
- Higher dose FA (500 μg/mL) showed stronger therapeutic effect than lower dose (200 μg/mL)
- ICC confirmed FA decreased CCL17 and CCL22 protein expression in stimulated HaCaT cells
Combined in vitro and in vivo study demonstrating fulvic acid’s mechanism of action in atopic dermatitis. In keratinocyte cell culture, FA inhibited CCL17/CCL22 chemokine expression via p38 MAPK and JNK pathway deactivation. These chemokines are key drivers of Th2 cell recruitment to AD lesions. In the DNCB-induced AD mouse model, topical FA dose-dependently reduced clinical symptoms (ear thickness, redness, scaling) and serum chemokine levels. This is one of the most mechanistically detailed studies of FA in dermatological application, identifying specific signaling pathways rather than just observing effects.
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FA attenuates AD by downregulating CCL17/CCL22 via p38 MAPK and JNK in keratinocytes
Topical FA attenuated DNCB-induced AD in mice: reduced ear thickness, erythema, serum CCL17/CCL22; inhibits p38 MAPK and JNK in keratinocytes; dose-dependent effect at 200-500 μg/mL
FA acts on p38 MAPK/JNK in keratinocytes — same pathways in hair follicle cycling
Topical FA attenuated DNCB-induced AD in mice: reduced ear thickness, erythema, serum CCL17/CCL22; inhibits p38 MAPK and JNK in keratinocytes; dose-dependent effect at 200-500 μg/mL
FA attenuates AD by downregulating CCL17/CCL22 via p38 MAPK and JNK in keratinocytes
FA acts on p38 MAPK/JNK in keratinocytes — same pathways in hair follicle cycling
FA inhibits CCL17/CCL22 in keratinocytes via p38 MAPK and JNK deactivation; dose-dependent in DNCB-induced AD mice
FA attenuates AD by downregulating CCL17/CCL22 via p38 MAPK and JNK inhibition in keratinocytes and DNCB mouse model