Application of topical peloid-derived humic acid suppresses allergic contact dermatitis
in-vitro Grade C 2020 Open access
Authors: Zhernov, Y.V.
Journal: World Allergy Organization Journal 13 (8) : P120
Key Findings
- Topical peloid-derived humic acid (HA) suppressed DNCB-induced allergic contact dermatitis (ACD) in mice
- HA reduced serum histamine levels in ACD mice
- HA suppressed DNCB-induced expression of IFN-γ, IL-4, IL-10, IL-13, IL-17, and TNF-α in ACD tissue
- HA inhibits inflammatory cell infiltration and production of inflammatory cytokines in skin
- HA treatment results in anti-inflammatory effects capable of inhibiting ACD by inducing immunosuppressive responses
- Authors conclude HA is a promising therapeutic for ACD with relevance to broad range of allergic and inflammatory skin diseases
Conference abstract (poster P120) demonstrating that topical peloid-derived humic acid suppresses allergic contact dermatitis in a DNCB-induced mouse model. HA significantly inhibited multiple inflammatory cytokines (IFN-γ, IL-4, IL-10, IL-13, IL-17, TNF-α) and reduced serum histamine. The broad cytokine suppression profile suggests HA acts via immunosuppressive mechanisms rather than targeting a single pathway, making it potentially relevant to multiple allergic and inflammatory skin conditions. Author attribution based on referenced works (Zhernov et al. 2017, Avvakumova et al. 2018); exact author list may include additional co-authors.
humic-acidpeloidallergic-contact-dermatitisanti-inflammatoryimmunosuppressivecytokinesmouse-model