Structure-antioxidant activity relationships of flavonoids and phenolic acids
review Grade A 1996
Authors: Rice-Evans, C.A., Miller, N.J., Paganga, G.
Journal: Free Radical Biology and Medicine
Key Findings
- Establishes structure-activity relationships for phenolic antioxidants
- Phenolic hydroxyl groups are the key structural feature for free radical scavenging
- Framework applicable to understanding peat phenolic antioxidant activity
Highly cited foundational paper establishing structure-activity relationships for phenolic antioxidants. Demonstrates that the number and position of hydroxyl groups on aromatic rings determines free radical scavenging capacity. Directly applicable to understanding why peat phenolics (humic acids, tannins, free phenolics) exhibit antioxidant activity.
phenolicsantioxidantstructure-activityflavonoidsfree-radicalsfoundational