Sphagnum cuspidatulum extract prevents acute kidney injury induced by high-fat diet and streptozotocin via alleviation of oxidative stress and apoptosis in pre-diabetic rats
Key Findings
- Sphagnum cuspidatulum extract (100 mg/kg) dramatically lowered serum creatinine, BUN, and improved creatinine clearance in pre-diabetic rats
- SC extract significantly decreased malondialdehyde (oxidative stress marker) and upregulated Nrf2 antioxidant pathway
- SC extract downregulated apoptotic markers in kidney tissue
- Sphagnum rich in phenolic compounds including caffeine — GC-MS characterization of bioactive compounds
- Demonstrates in-vivo antioxidant and renoprotective activity of sphagnum moss extract
Animal study demonstrating that Sphagnum cuspidatulum extract has significant antioxidant and renoprotective effects in pre-diabetic rats. The extract, rich in phenolic compounds, activates the Nrf2 antioxidant pathway and reduces oxidative stress markers.
Key Data
- Model: Male Wistar rats on high-fat diet + low-dose streptozotocin (pre-diabetic model)
- Doses tested: SC 50 mg/kg/day and SC 100 mg/kg/day vs. metformin 100 mg/kg/day
- Duration: 4 weeks by gavage
- SC100 results: Lowered serum creatinine, BUN; improved creatinine clearance; decreased MDA; upregulated Nrf2 and downstream mediators; downregulated apoptotic markers
Significance for Knowledge Graph
First in-vivo study of sphagnum moss extract showing pharmacological activity beyond antimicrobial effects. Demonstrates that sphagnum phenolics have systemic antioxidant activity via the Nrf2 pathway — not just local/topical effects. Identifies caffeine as a bioactive compound in sphagnum, which was not previously in the knowledge graph. Provides scientific basis for broader therapeutic applications of sphagnum-derived compounds.
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Sphagnum phenolics activate Nrf2 pathway, reduce oxidative stress in vivo (rat study)
Sphagnum phenolics activate Nrf2 antioxidant pathway in vivo
Sphagnum extract activates Nrf2 antioxidant pathway in vivo, reduces MDA